Optimizing Hippocampal-Cortical Network Modulation via Repetitive Transcranial Magnetic Stimulation: A Dose-Finding Study Using the Continual Reassessment Method.
Michael V FreedbergJack A ReevesAndrew C ToaderMolly S HermillerEunhee KimDietrich HaubenbergerYing Kuen CheungJoel L VossEric M WassermannPublished in: Neuromodulation : journal of the International Neuromodulation Society (2019)
The CRM can be adapted for rTMS dose finding when a reliable outcome measure, such as FC, is available. The minimum effective dose needed to produce a criterion increase in FC in our hippocampal network of interest at 87.5% efficacy was estimated to be greater than four sessions. This study is the first demonstration of a Bayesian, adaptive method to explore a rTMS parameter.