Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis.

Changcheng GuoYin SunWei ZhaiXudong YaoDongkui GongBosen YouChi-Ping HuangJunhua ZhengChawnshang Chang

Published in: Cell & bioscience (2022)

Together, these findings suggest that hypoxia may increase the RCC CSC phenotype via altering the AR/lncTCFL5-2/YBX1/SOX2 signaling axis and a potential therapy to target this newly identified signal perhaps may help improve the targeted therapy with Sunitinib to better suppress RCC progression.

Keyphrases

renal cell carcinoma
stem cells
transcription factor
endothelial cells
risk assessment
mesenchymal stem cells
metastatic renal cell carcinoma
replacement therapy