Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1-mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma.

Sarita SaraswatiAbdulqader AlhaiderAbdelgalil Mohamed AbdelgadirPooja TanwerHesham Mohamed Korashy

Published in: Cell communication and signaling : CCS (2019)

Our data suggest that PH inhibits STAT3 activity in Sor-sensitive and -resistant HCCs via SHP-1-mediated inhibition of STAT3 and AKT/mTOR/JAK2/VEGFR2 pathway. Our results clearly indicate that PH may be a potent reagent for hepatocellular carcinoma and a noveltargeted therapy for further clinical investigations.

Keyphrases

cell proliferation
signaling pathway
vascular endothelial growth factor
electronic health record
big data
machine learning
drug delivery