Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease.
Brian Matthew LangL BiedermannW T van HaaftenC de VallièreM SchuurmansS BegréJ ZeitzM ScharlM TurinaT GreuterP SchreinerHenriette HeinrichT KuntzenS R VavrickaG RoglerNiko BeerenwinkelBenjamin Misselwitznull nullPublished in: Alimentary pharmacology & therapeutics (2017)
SNPs associated with smoking quantity is associated with an increased risk for surgery in Crohn's disease patients who smoke. Our data provide an example of genetics interacting with the environment to influence the disease course of inflammatory bowel disease.