Interferon-λ3 Exacerbates the Inflammatory Response to Microbial Ligands: Implications for SARS-CoV-2 Pathogenesis.

Scott A ReadBrian S GlossChristopher LiddleJacob GeorgeGolo Ahlenstiel

Published in: Journal of inflammation research (2021)

These data suggest that IFN-λs contribute to disease pathology by exacerbating innate immune responses during chronic or severe disease states. IFN-λs may contribute to SARS-CoV-2 disease severity, however further study is required to confirm true causation.

Keyphrases

immune response
sars cov
dendritic cells
inflammatory response
respiratory syndrome coronavirus
toll like receptor
microbial community
early onset
lipopolysaccharide induced
electronic health record
drug induced
deep learning