Cellular Adaptation Relies on Regulatory Proteins Having Episodic Memory: Proteins Modulate Cell Metabolism and Reproduction by Remembering, Transmitting, and Using Data on the Environment.
Razvan Costin StanDarshak K BhattMaristela M de CamargoPublished in: BioEssays : news and reviews in molecular, cellular and developmental biology (2019)
The ability to memorize changes in the environment is present at all biological levels, from social groups and individuals, down to single cells. Trans-generational memory is embedded subcellularly through genetic and epigenetic mechanisms. Evidence that cells process and remember features of the immediate environment using protein sensors is reviewed. It is argued that this mnemonic ability is encapsulated within the protein conformational space and lasts throughout its lifetime, which can overlap with the lifespan of the organism. Means to determine diachronic changes in protein activity are presented.
Keyphrases
- induced apoptosis
- cell cycle arrest
- protein protein
- working memory
- healthcare
- binding protein
- gene expression
- mental health
- single cell
- oxidative stress
- molecular dynamics
- small molecule
- signaling pathway
- mesenchymal stem cells
- genome wide
- cell therapy
- molecular dynamics simulations
- cell proliferation
- big data
- pi k akt