Multiple Myeloma: Case of a "Moving" Sternal Wire.
Yun Song ChooMelissa Gaik-Ming OoiShi WangJames Thomas Patrick Decourcy HallinanPublished in: Diagnostics (Basel, Switzerland) (2023)
Multiple myeloma generally occurs in older adults, with the clonal proliferation of plasma cells and accumulation of monoclonal protein resulting in a broad range of clinical manifestations and complications, including hypercalcemia, renal dysfunction, anaemia, and bone destruction (termed CRAB features). A 64-year-old man with no history of malignancy presented with an enlarging precordial lump occurring three years post-sternotomy for uneventful coronary artery bypass grafting surgery. Initial investigations showed anaemia and impaired renal function. Multimodal imaging performed for further evaluation showcases the radio-pathological features which can be encountered in haematological malignancy. Subsequent percutaneous biopsy confirmed an underlying plasma cell neoplasm, and a diagnosis of multiple myeloma was achieved. The prompt resolution of the lesions upon the initiation of treatment highlights the importance of early diagnosis and treatment.
Keyphrases
- multiple myeloma
- coronary artery bypass grafting
- minimally invasive
- induced apoptosis
- percutaneous coronary intervention
- coronary artery disease
- ultrasound guided
- signaling pathway
- cell cycle arrest
- coronary artery bypass
- iron deficiency
- oxidative stress
- single cell
- physical activity
- risk factors
- low grade
- cell therapy
- stem cells
- heart failure
- mesenchymal stem cells
- community dwelling
- cell death
- endoplasmic reticulum stress
- middle aged
- binding protein
- atrial fibrillation
- surgical site infection
- small molecule
- bone regeneration
- photodynamic therapy
- postmenopausal women
- aortic valve