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Identification of anti-pathogenic activity among in silico predicted small-molecule inhibitors of Pseudomonas aeruginosa LasR or nitric oxide reductase (NOR).

Gemini GajeraNiel HenriksenBryan CoxVijay Kothari
Published in: Drug target insights (2023)
Further investigation on molecular mode of action of compounds found active in this study is warranted. Virtual screening can be said to be a useful tool in narrowing down the list of compounds requiring actual wet-lab screening, saving considerable time and efforts for drug discovery.
Keyphrases
  • drug discovery
  • small molecule
  • nitric oxide
  • pseudomonas aeruginosa
  • cystic fibrosis
  • molecular docking
  • hydrogen peroxide
  • biofilm formation
  • quality improvement
  • staphylococcus aureus
  • candida albicans