Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Vulnerabilities to MEK Inhibition in Lung Adenocarcinoma.

Anneleen DaemenJonathan E Cooper Szymon Myrta Matthew J WongchenkoEva LinJason E LongOded ForemanZora ModrusanJarrod R TremayneCecile C de la CruzMark MerchantScott E MartinYibing YanMelissa R Junttila

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Our findings support forward translational relevance of transcriptional subtypes, where further exploration therein may improve lung adenocarcinoma treatment.See related commentary by Skoulidis, p. 913.

Keyphrases

gene expression
single cell
heat shock
pi k akt
signaling pathway
replacement therapy
drug induced
heat shock protein