Attenuated airway hyperresponsiveness and mucus secretion in HDM-exposed Igf1r-deficient mice.

Herein, we demonstrate by the first time that the Igf1r plays an important role in murine asthma, mediating both AHR and mucus secretion after HDM exposure. Thus, our study identifies IGF1R as a potential therapeutic target, not only for asthma but also for hypersecretory airway diseases.