Tumour catabolism independent of malnutrition and inflammation in upper GI cancer patients revealed by longitudinal metabolomics.
Janusz von RenesseFelix von BechtolsheimSophie JonasLena SeifertTiago C AlvesAdrian M SeifertFilip KomorekGuergana TritchkovaMario MenschikowskiUlrich BorkRonny MeisterfeldMarius DistlerTriantafyllos ChavakisJürgen WeitzAlexander M FunkChristoph KahlertPeter MirtschinkPublished in: Journal of cachexia, sarcopenia and muscle (2022)
H NMR spectroscopy identified a tumour-induced catabolic signature specific to upper gastrointestinal cancer patients and enabled monitoring restoration of metabolic homeostasis after surgery. This approach was critical to identify the obtained metabolic profile as an upper gastrointestinal cancer-specific signature independent of malnutrition and inflammation.