Mass spectrometry imaging identifies metabolic patterns associated with malignant potential in pheochromocytoma and paraganglioma.
Masanori MurakamiNa SunChristian GreunkeAnnette FeuchtingerStefan KircherTimo DeutschbeinThomas PapathomasNicole BechmannPaal William WallaceMirko PeitzschEsther KorpershoekJuliane FriemelAnne-Paule Gimenez-RoqueploMercedes RobledoHenri J L M TimmersLetizia CanuAchim WeberRonald R de KrijgerMartin FassnachtThomas KnöselThomas KirchnerMartin ReinckeAxel Karl WalchMatthias KroissFelix BeuschleinPublished in: European journal of endocrinology (2021)
The present study has identified distinct tissue metabolomic profiles of PPGLs in relation to tumor genotypes. In addition, we revealed significantly altered metabolites in the kynurenine pathway in metastatic PPGLs, which can aid in the prediction of its malignant potential. However, further validation studies will be required to confirm our findings.