Cognitive Practice Effects Delay Diagnosis; Implications for Clinical Trials.
Mark Sanderson-CiminoJeremy A ElmanXin M TuAlden L GrossMatthew S PanizzonDaniel E GustavsonMark W BondiEmily C EdmondsGraham M L EglitJoel S EppigCarol E FranzAmy J JakMichael J LyonsKelsey R ThomasMcKenna E WilliamsWilliam S KremenPublished in: medRxiv : the preprint server for health sciences (2020)
Adjusting for practice effects on cognitive testing leads to earlier detection of MCI. When MCI is an outcome, this reduces recruitment needed for clinical trials, study duration, staff and participant burden, and can dramatically lower costs. Importantly, biomarker evidence also indicates improved diagnostic accuracy.