Altered fibrin network structure and fibrinolysis in intensive care unit patients with COVID-19, not entirely explaining the increased risk of thrombosis.

Judith J de Vries Chantal Visser Lotte Geers Johan A Slotman Nadine D van Kleef Coen Maas Hannelore I Bax Jelle R Miedema Eric C M van Gorp Marco Goeijenbier Johannes P C van den Akker Henrik Endeman Dingeman C Rijken Marieke J H A Kruip Moniek P M de Maat

Published in: Journal of thrombosis and haemostasis : JTH (2022)

Our results suggest that severe COVID-19 is associated with a changed fibrin network structure and decreased susceptibility to fibrinolysis. Because these changes were not exclusive to COVID-19 patients, they may not explain the increased thrombosis risk.

Keyphrases

intensive care unit
sars cov
pulmonary embolism
coronavirus disease
platelet rich plasma
mechanical ventilation
early onset
respiratory syndrome coronavirus
drug induced
network analysis
extracorporeal membrane oxygenation
acute respiratory distress syndrome
bone regeneration