Association between Obesity, Race or Ethnicity, and Luminal Subtypes of Breast Cancer.
Kalhara R MenikdiwelaChanaka KahathuduwaMichelle L BolnerRakhshanda Layeequr RahmanNaima Moustaid-MoussaPublished in: Biomedicines (2022)
Luminal breast cancers are the most common genomic subtype of breast cancers where Luminal A cancers have a better prognosis than Luminal B. Exposure to sex steroids and inflammatory status due to obesity are key contributors of Luminal tumor development. In this study, 1928 patients with Luminal A breast cancer and 1610 patients with Luminal B breast cancer were compared based on body mass index (BMI), age, race, menopausal status, and expressed receptors (i.e., estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2)). Patients with Luminal B tumors had a significantly higher mean BMI (Δ = 0.69 kgm -2 [0.17, 1.21], p = 0.010) versus Luminal A. Interestingly, the risks of Luminal B tumors were higher among Black/African American patients versus White and Hispanic patients ( p < 0.001 and p = 0.001, respectively). When controlled for each other, Black/African American race ( p < 0.001) and increased BMI ( p = 0.008) were associated with increased risks of Luminal B carcinoma, while postmenopausal status was associated with a decreased risk ( p = 0.028). Increased BMI partially mediated the strong association between Black/African American race and the risk of Luminal B carcinoma. Thus, Black/African American race along with obesity seem to be associated with an increased risk of more aggressive Luminal B breast carcinomas.
Keyphrases
- african american
- body mass index
- weight gain
- insulin resistance
- epidermal growth factor receptor
- type diabetes
- end stage renal disease
- ejection fraction
- weight loss
- chronic kidney disease
- endothelial cells
- oxidative stress
- prognostic factors
- adipose tissue
- skeletal muscle
- gene expression
- high fat diet induced
- tyrosine kinase
- patient reported outcomes
- estrogen receptor
- young adults
- genome wide
- postmenopausal women
- patient reported
- copy number