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Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction.

Chen GaoZhaojun XiongYunxia LiuMeng WangMenglong WangTian LiuJianfang LiuShuxun RenNancy CaoHai YanDaniel J DruckerChristoph Daniel RauTomohiro YokotaJijun HuangYibin Wang
Published in: Circulation research (2024)
These findings identify glucagon receptor signaling in cardiomyocytes as a critical determinant of HFpEF progression and provide proof-of-concept support for glucagon receptor antagonism as a potential therapy for the disease.
Keyphrases
  • human health
  • risk assessment
  • endothelial cells
  • binding protein