Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction.
Chen GaoZhaojun XiongYunxia LiuMeng WangMenglong WangTian LiuJianfang LiuShuxun RenNancy CaoHai YanDaniel J DruckerChristoph Daniel RauTomohiro YokotaJijun HuangYibin WangPublished in: Circulation research (2024)
These findings identify glucagon receptor signaling in cardiomyocytes as a critical determinant of HFpEF progression and provide proof-of-concept support for glucagon receptor antagonism as a potential therapy for the disease.