[18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM.
Eline E VerwerTaylor R KavanaghWilliam J MischlerYou FengKazue TakahashiShuyan WangTimothy M ShoupRamesh NeelamegamJing YangNicolas J GuehlChongzhao RanWalter MassefskiYe CuiSouheil El-ChemalyPeter M SadowWilliam M OldhamMarie F KijewskiGeorges El FakhriMarc D NormandinCarmen PrioloPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Preclinical models of TSC2 deficiency represent informative platforms to identify tracers of potential clinical interest. Our findings provide mechanistic evidence for testing the potential of [18F]FCH and [18F]FACE as metabolic imaging biomarkers for TSC and LAM proliferative lesions, and novel insights into the metabolic reprogramming of TSC tumors.