The Mycobacterium tuberculosis MmpL3 inhibitor MSU-43085 is active in a mouse model of infection.

John T WilliamsMatthew GilettoElizabeth R HaidererBilal AleiwiTeresa Krieger-BurkeEdmund EllsworthRobert B Abramovitch

Published in: Microbiology spectrum (2023)

metabolism of MSU-43085, leading to a short half-life in treated mice. These proof-of-concept studies will guide further development of the MSU-43085 series for the treatment of TB or NTM infections.

Keyphrases

mycobacterium tuberculosis
mouse model
pulmonary tuberculosis
high fat diet induced
type diabetes
insulin resistance
replacement therapy