TF-FVIIa PAR2-β-Arrestin Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection of Mice.

Meike Kespohl Carl Christoph GoetzkeNadine AlthofClara BredowNicolas KelmSandra PinkertThomas BukurValesca BukurKristin GrunzDilraj KaurArnd HeuserMichael Mulleder Martina Sauter Karin KlingelHartmut WeilerNikolaus Berndt Matthias M Gaida Wolfram Ruf Antje Beling

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

These data provide insights into a TF-FVIIa signaling axis through PAR2-β-arrestin coupling that is a regulator of inflammation-triggered tissue repair and hemodynamic compromise in coxsackievirus B3 infection and can potentially be targeted with selective coagulation inhibitors.

Keyphrases

oxidative stress
transcription factor
high fat diet induced
big data
room temperature
metabolic syndrome
drug delivery