Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation.

Mayilaadumveettil NishanaCaryn HaJavier Rodriguez-HernaezAli RanjbaranErica ChioElphege P NoraSana B BadriAndreas KloetgenBenoit G BruneauAristotelis TsirigosJane A Skok

Published in: Genome biology (2020)

This study clarifies the unique and combined contribution of CTCF and CTCFL to chromosome organization and transcription, with direct implications for understanding how their co-expression deregulates transcription in cancer.

Keyphrases

transcription factor
copy number
papillary thyroid
squamous cell
binding protein
gene expression
dna methylation
lymph node metastasis
childhood cancer