Second generation Al 18 F-labeled D-amino acid peptide for CXCR4 targeted molecular imaging.
Muriel Aline SpahnKaat LuytenTom Van LoyMike SathekgeChristophe M DerooseMichel KooleDominique ScholsWim VanduffelKristof De VosPieter AnnaertGuy BormansFrederik CleerenPublished in: Nuclear medicine and biology (2024)
F]AlF-NOTA-2xDV1(c11sc12s) is not specific for CXCR4 and is also a substrate for OATP1B1 and/or OATP1B3, known to mediate hepatic uptake. Therefore, D-amino acid peptides, based on the viral macrophage inflammatory protein II, are not the prefered vector molecule for the development of CXCR4 targeting molecular imaging tools.