Comparing the clinical significance and antigen specificity of insulinoma-associated antigen-2 autoantibodies between radioimmunoassay and enzyme-linked immunosorbent assay in Japanese patients with type 1 diabetes.
Eiji KawasakiAkira ShimadaAkihisa ImagawaNorio AbiruTakuya AwataYoichi OikawaHaruhiko OsawaYumiko KawabataJunji KozawaTetsuro KobayashiKazuma TakahashiDaisuke ChujoTomoyasu FukuiJunnosuke MiuraKazuki YasudaHisafumi YasudaHiroshi KajioToshiaki HanafusaHiroshi Ikegaminull nullPublished in: Journal of diabetes investigation (2022)
These results suggest that IA-2A-ELISA is a reliable marker not only for the diagnosis of type 1 diabetes, but also for the prediction of future insulin dependency; that is, detection of IA-2A-ELISA helps identify a subtype of SPIDDM patients who would likely progress onto insulin-deficient state.