Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/ tropical spastic paraparesis.

Luana Leandro GoisBárbara Ribeiro-SoaresCarlos Gustavo Regis-SilvaDalila L ZanetteRaphaella LisboaRegina Santos NascimentoRaimundo Coutinho JuniorBernardo Galvão-CastroMaria Fernanda Rios Grassi

Published in: BMC infectious diseases (2024)

A higher frequencies of IL10-producing Tregs were identified in patients with HAM/TSP. Imbalanced production of IL10 in relation to TGF-β may contribute to the increased inflammatory response characteristically seen in HAM/TSP patients.

Keyphrases

inflammatory response
end stage renal disease
transforming growth factor
chronic kidney disease
ejection fraction
newly diagnosed
spinal cord
climate change
prognostic factors
peritoneal dialysis
spinal cord injury
cerebral palsy
signaling pathway
patient reported outcomes
epithelial mesenchymal transition