Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice.

Tevin C Y ChauSungmin BaekBaptiste CoxamRenae SkoczylasMaria Rondon-GaleanoNeil I BowerElanor N WainwrightSteven A StackerHelen M CooperPeter A KoopmanAnne K LagendijkNatasha L HarveyMathias FrançoisBenjamin M Hogan

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)

Our work suggests that Pkd1 acts at least in part by regulating non-canonical WNT signaling during the formation of lymphatic vascular networks.

Keyphrases

polycystic kidney disease
lymph node
stem cells
cell proliferation
high fat diet induced
metabolic syndrome
insulin resistance
skeletal muscle
wild type