Synthesis of C -Oligosaccharides via Ni-Catalyzed Reductive Hydroglycosylation.

C -Oligosaccharides are metabolically stable surrogates of native glycans containing O / N / S -glycosidic linkages and thus have therapeutic potential. Here we report a straightforward approach to the synthesis of vinyl C -linked oligosaccharides via the Ni-catalyzed reductive hydroglycosylation of alkynyl glycosides with glycosyl bromides.