Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges.
Bhuvi SachdevaPunya SachdevaArvind NegiShampa GhoshSung Soo HanSaikat DewanjeeSaurabh Kumar JhaRakesh BhaskarJitendra Kumar SinhaAna Cláudia Paiva SantosNiraj Kumar JhaKavindra Kumar KesariPublished in: Marine drugs (2023)
Chitin is the second most abundant biopolymer consisting of N -acetylglucosamine units and is primarily derived from the shells of marine crustaceans and the cell walls of organisms (such as bacteria, fungi, and algae). Being a biopolymer, its materialistic properties, such as biodegradability, and biocompatibility, make it a suitable choice for biomedical applications. Similarly, its deacetylated derivative, chitosan, exhibits similar biocompatibility and biodegradability properties, making it a suitable support material for biomedical applications. Furthermore, it has intrinsic material properties such as antioxidant, antibacterial, and antitumor. Population studies have projected nearly 12 million cancer patients across the globe, where most will be suffering from solid tumors. One of the shortcomings of potent anticancer drugs is finding a suitable cellular delivery material or system. Therefore, identifying new drug carriers to achieve effective anticancer therapy is becoming essential. This paper focuses on the strategies implemented using chitin and chitosan biopolymers in drug delivery for cancer treatment.
Keyphrases
- drug delivery
- cancer therapy
- drug release
- anti inflammatory
- single cell
- papillary thyroid
- wound healing
- oxidative stress
- cell therapy
- hyaluronic acid
- stem cells
- tissue engineering
- emergency department
- decision making
- drug induced
- mesenchymal stem cells
- bone marrow
- young adults
- essential oil
- electronic health record
- plant growth
- childhood cancer