Late-onset megaconial myopathy in mice lacking group I Paks.
Giselle A JosephMargaret HungAviva J GoelMingi HongMarysia-Kolbe RiederNoam D BeckmannMadhavika N SerasingheJerry E ChipukParvathi M DevarakondaDavid J GoldhamerPaulina Aldana-HernandezJonathan CurtisRené L JacobsRobert S KraussPublished in: Skeletal muscle (2019)
Conditional loss of Pak1 and Pak2 in mice resulted in an age-dependent myopathy with similarity to mice and humans with CHKβ deficiency. Protein kinases are major regulators of most biological processes but few have been implicated in muscle maintenance or disease. Pak1/Pak2 dKO mice offer new insights into these processes.