Delayed vaccine-induced CD8 + T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication.
Tetje Cornelia van der SluisFloortje J van HaftenSuzanne van DuikerenIris N PardieckJ Fréderique de GraafWard VleeshouwersKoen van der MaadenCornelis J M MeliefSjoerd H van der BurgRamon ArensPublished in: Journal for immunotherapy of cancer (2023)
Taken together, our data show that although treatment with cisplatin, topotecan and vaccination initially delays T cell expansion, this combinatorial therapy results eventually in a more robust T cell-mediated tumor eradication due to enhancement of costimulatory molecules in the TME.