Neuropsychiatric adverse effects of synthetic glucocorticoids: A systematic review and meta-analysis.

Anne-Sophie C A M Koning Merel van der MeulenDaphne SchaapDjaina D Satoer Christiaan H Vinkers Elisabeth F C van Rossum Wouter R van Furth Alberto M Pereira Onno C Meijer Olaf M Dekkers

Published in: The Journal of clinical endocrinology and metabolism (2023)

The heterogeneity of glucocorticoid use is reflected in the available studies. Despite this heterogeneity, the proportion of neuropsychiatric adverse effects in glucocorticoid users is high. The most substantial associations with glucocorticoid use were found for depression and mania. Upon starting glucocorticoid treatment, awareness of possible psychiatric side effects is essential. More structured studies on incidence and potential pathways of neuropsychiatric side effects of prescribed glucocorticoids are clearly needed.

Keyphrases

single cell
depressive symptoms
risk factors
physical activity
combination therapy
climate change