The future of safety science is happening now: The modernization of the benefit-risk paradigm.
Fabio LievanoLinda ScarazziniFrank ShenJames DuhigJeremy D JokinenPublished in: Pharmacoepidemiology and drug safety (2017)
The future of safety science is happening now and has the potential to improve patient outcomes through an evolving approach to benefit-risk assessment. Three building blocks for the future of safety science, cognitive and behavioral systems, medical assessment, and data science, individually and collaboratively advance and modernize the benefit-risk paradigm. Incorporating the patient perspective and patient experiences will help identify tools that are useful in real-world practice. Medical assessment teams will bring together the study of toxicity and toxicogenomics, biomarkers, and special populations to personalize the benefit-risk profile. Personalized benefit-risk profiles for patients will help improve outcomes. Data science and related quantitative sciences such as safety statistics, database integration, technology, and epidemiology will provide new approaches and tools for analysis of safety data as well as more rapid access to insights that benefit patients.
Keyphrases
- public health
- end stage renal disease
- risk assessment
- healthcare
- ejection fraction
- newly diagnosed
- chronic kidney disease
- electronic health record
- big data
- primary care
- prognostic factors
- mental health
- type diabetes
- case report
- oxidative stress
- metabolic syndrome
- artificial intelligence
- mass spectrometry
- skeletal muscle
- machine learning
- weight loss
- quality improvement
- sensitive detection
- clinical evaluation