RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling.

Jirong WangChengyun XuJing ZhangYizhong BaoYing TangXiaoling LvBo MaXimei WuGenxiang Mao

Published in: Molecular medicine (Cambridge, Mass.) (2023)

RhoA promoted osteoclast development via the Akt-mTOR-NFATc1 signaling pathway, resulting a osteoporosis phenotype, and that manipulating RhoA activity might be a therapeutic strategy for osteoporotic bone loss.

Keyphrases

bone loss
signaling pathway
cell proliferation
bone mineral density
postmenopausal women
pi k akt
induced apoptosis
epithelial mesenchymal transition
body composition
oxidative stress
endoplasmic reticulum stress