Influence of endplate avulsion and Modic changes on the inflammation profile of herniated discs: a proteomic and bioinformatic approach.
Niek DjuricDr Shanmuganathan RajasekaranChitra TangavelMuthurajan RaveendranDilip Chand Raja SoundararajanSharon Miracle NayagamMonica Steffi MatchadoK S Sri Vijay AnandAjoy Prasad ShettyRishi Mugesh KannaPublished in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2021)
Both EPA and MC status significantly influence disc inflammation. The beneficial inflammatory signature of EPA illustrates that endplate pathology does not necessarily have to worsen the outcome, but the pathological inflammatory state is dependent on the presence of MC.
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