Zebrafish Models of Cancer Therapy-Induced Cardiovascular Toxicity.
Sarah LaneLuis Alberto MoreAarti H AsnaniPublished in: Journal of cardiovascular development and disease (2021)
The high degree of genetic conservation between zebrafish and humans, as well as the ability to recapitulate cardiotoxic phenotypes observed in patients with cancer, make the zebrafish an effective model to study cancer therapy-associated cardiovascular toxicity. Though this model provides several key benefits over existing in vitro and in vivo models, limitations of the zebrafish model include the early developmental stage required for most high-throughput applications.