Contemporary national trends in prostate cancer risk profile at diagnosis.
Sean A FletcherNicolas von LandenbergAlexander P ColePhilipp GildToni K ChoueiriStuart R LipsitzQuoc-Dien TrinhAdam S KibelPublished in: Prostate cancer and prostatic diseases (2019)
The proportion of localized intermediate/high risk and metastatic PCa has substantially increased over the past decade, while the proportion of low-risk disease has decreased. This shift has been primarily driven by increased diagnosis of high-grade disease. National guidelines advising against PSA screening may have contributed to these findings.