Distinct structural and functional angiogenic responses are induced by different mechanical stimuli.
Roger W P KissanePeter G TickleNatalie E DoodyAbdullah A Al-ShammariStuart EggintonPublished in: Microcirculation (New York, N.Y. : 1994) (2021)
Targeted capillary growth in response to abluminal stretch is a potent driver of improved muscle fatigue resistance, while shear stress-driven angiogenesis has no beneficial effect on muscle function. In terms of capillarity, more is not necessarily better.