Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil.

Haoxin PengXiangrong WuShaopeng LiuMiao HeChenshuo TangYaokai WenChao XieRan ZhongCaichen LiShan XiongJun LiuHongbo ZhengJian-Xing HeXu LuWenhua Liang

Published in: Clinical and translational medicine (2023)

The cellular composition, spatial location, molecular and functional changes in PT and TDLN microenvironments along with NSCLC progression were deciphered, highlighting the immunoregulatory roles and evolutionary heterogeneity of TANs.

Keyphrases

single cell
genome wide
small cell lung cancer
advanced non small cell lung cancer
dna methylation
gene expression
epidermal growth factor receptor