Quantifying radiation therapy response using apparent diffusion coefficient (ADC) parametric mapping of pediatric diffuse intrinsic pontine glioma: a report from the pediatric brain tumor consortium.

Rafael CeschinMehmet KocakSridhar VajapeyamIan F PollackArzu Onar-ThomasIra J DunkelTina Young PoussaintAshok Panigrahy

Published in: Journal of neuro-oncology (2019)

Baseline ADC values are a stronger predictor of outcome compared to radiation related ADC changes in pediatric DIPG. We show the feasibility of employing parametric mapping techniques in multi-center studies to quantitate spatially heterogeneous treatment response in pediatric tumors, including DIPG.

Keyphrases

diffusion weighted imaging
radiation therapy
high resolution
magnetic resonance imaging
squamous cell carcinoma
low grade
high density
high grade