YCl3 Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats.

Yechun DingYuantong TianZhaoyi ZengPing ShuaiHaiying LanXianshen ZhuYi ZhongLonghuo Wu Xiaona Fan

Published in: BioMed research international (2017)

The pollutants rare earth elements (REEs) have posed great threats to human health. To investigate the cytotoxicity of yttrium (Y), a model that rats have free access to water containing YCl3 for 6 months is utilized. The results showed that YCl3 treatment promoted neuronal cell apoptosis by upregulating the proapoptotic factors Bax, caspase-3, Cyto c, and DAPK and by downregulating the antiapoptotic factors Bcl-2 and XIAP at both mRNA and protein levels. Conclusively, YCl3 exhibited cytotoxicity and promoted neuronal cell death by the induction of apoptotic pathways.

Keyphrases

cell death
human health
risk assessment
cell cycle arrest
cerebral ischemia
climate change
binding protein
cell proliferation
heavy metals
induced apoptosis
combination therapy
protein protein
anti inflammatory
replacement therapy