Elevated LDL (Low-Density Lipoprotein) Cholesterol Increases Microvascular Endothelial VWF (von Willebrand Factor) and Thromboinflammation After Myocardial Infarction.

In reperfused myocardial infarction, elevated LDL cholesterol promotes thromboinflammation through excess microvascular endothelial VWF and platelet adhesion, resulting in less microvascular reflow and larger infarct size. In the presence of elevated LDL cholesterol, therapies that suppress endothelial-associated VWF can promote recovery of left ventricular function and protect against remodeling.