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Protective Effects of Two Safflower Derived Compounds, Kaempferol and Hydroxysafflor Yellow A, on Hyperglycaemic Stress-Induced Podocyte Apoptosis via Modulating of Macrophage M1/M2 Polarization.

Yuanping LiDan ZhengDayue ShenXilan ZhangXiaoyun ZhaoHui Liao
Published in: Journal of immunology research (2020)
The protective effects of Ka and HSYA on podocyte apoptosis under hyperglycemic stress are related to their modulation on M1/M2 polarization and the lowering effects on TNF-α and IL-1β levels.
Keyphrases
  • stress induced
  • endoplasmic reticulum stress
  • cell cycle arrest
  • oxidative stress
  • diabetic nephropathy
  • cell death
  • rheumatoid arthritis
  • high glucose
  • endothelial cells
  • pi k akt