PKCε phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration.

Varun KumarYi-Chinn WengYu-Chieh WuYu-Ting HuangWen-Hai Chou

Published in: BMC neuroscience (2018)

Our results support the hypothesis that PKCε regulates phosphorylation and nuclear sequestration of ATF2 in hippocampal neurons during ischemia-induced neurodegeneration.

Keyphrases

high glucose
diabetic rats
protein kinase
oxidative stress
transcription factor
endoplasmic reticulum stress
spinal cord
endothelial cells