Deletion of ATAD3A inhibits osteogenesis by impairing mitochondria structure and function in pre-osteoblast.

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2022)

The current findings suggest that ATAD3A plays a crucial role in mitochondria homeostasis, which is required for osteogenic differentiation during skeletal development.

Keyphrases

cell death
endoplasmic reticulum
reactive oxygen species
mesenchymal stem cells
bone regeneration
bone marrow