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Emergence of Ceftolozane-Tazobactam-Resistant Pseudomonas aeruginosa during Treatment Is Mediated by a Single AmpC Structural Mutation.

Shawn H MacVaneRuchi PandeyLisa L SteedBarry N KreiswirthLiang Chen
Published in: Antimicrobial agents and chemotherapy (2017)
Ceftolozane-tazobactam is a cephalosporin-β-lactamase inhibitor combination that exhibits potent in vitro activity against Pseudomonas aeruginosa, including strains that are resistant to other β-lactams. The emergence of ceftolozane-tazobactam resistance among clinical isolates of P. aeruginosa has rarely been described. Here we characterized ceftolozane-tazobactam-resistant P. aeruginosa strains recovered from a patient who was treated with this agent for 6 weeks for a recurrent wound infection. The results showed that the resistance was mediated by a single AmpC structural mutation.
Keyphrases
  • gram negative
  • multidrug resistant
  • pseudomonas aeruginosa
  • acinetobacter baumannii
  • escherichia coli
  • cystic fibrosis
  • drug resistant
  • biofilm formation