Genetic profiling as a clinical tool in advanced parathyroid carcinoma.

Merve KutahyaliogluHa T NguyenLily KwatamporaCallisia ClarkeAngelica SilvaEiman IbrahimSteven G WaguespackMaria E CabanillasCamilo JimenezMimi I HuSteven I ShermanScott KopetzRussell BroaddusRamona DaduKacey WanlandMichelle WilliamsMark ZafereoNancy PerrierNaifa L Busaidy

Published in: Journal of cancer research and clinical oncology (2019)

Mutational profiling using NGS panels in advanced PC has yielded important potentially targetable genetic alterations. Larger studies are needed to identify commonly mutated genes in advanced PC patients. Development of novel therapies targeting these cellular pathways should be considered.

Keyphrases

genome wide
ejection fraction
newly diagnosed
single cell
copy number
prognostic factors
gene expression
dna methylation
cancer therapy
drug delivery