The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy.

Katrine IngelshedDiana Spiegelberg Pavitra Kannan Linnéa PåvéniusJessica HacheneyLong JiangSilke EisingerDanai LianoudakiDilraj Lama Francisca CastilloCecilia BosdotterWarren W KretzschmarOmayma Al-RadiNicolas FritzEduardo J VillablancaMikael C I KarlssonFredrik Wermeling Marika NestorDavid P LaneSaikiran K Sedimbi

Published in: Cancer research communications (2022)

The MDM2 inhibitor Navtemadlin arrests mouse tumor growth and potentiates radiotherapy. Our results support a threshold model for apoptosis induction that requires a high, prolonged p53 signaling for cancer cells to become apoptotic.

Keyphrases

early stage
cell death
locally advanced
cardiopulmonary resuscitation
radiation therapy
radiation induced
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
cardiac arrest
squamous cell carcinoma
signaling pathway
cell proliferation