New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum.

Lis LoboLília I L CabralMaria Inês SenaBruno GuerreiroAntónio Sebastião RodriguesValter Ferreira de Andrade-NetoMaria L S CristianoFatima Nogueira

Published in: Malaria journal (2018)

The investigated, trioxolane-tetrazole conjugates LC131 and LC136 emerged as potential anti-malarial candidates; they show negligible toxicity towards mammalian cells, ability to kill intra-erythrocytic asexual stages of artemisinin-resistant P. falciparum and capacity to totally suppress P. berghei parasitaemia in mice.

Keyphrases

plasmodium falciparum
simultaneous determination
mass spectrometry
oxidative stress
liquid chromatography
high fat diet induced
cancer therapy
atomic force microscopy
risk assessment
skeletal muscle
adipose tissue
high resolution
high speed