Genome-Wide Analysis Identifies Nuclear Factor 1C as a Novel Transcription Factor and Potential Therapeutic Target in SCLC.

Vivek ShuklaHaitao WangLyuba VarticovskiSongjoon BaekRuihong WangXinwei WuFrank EchtenkampFrank Villa-HernandezKatherine P ProthroSudheer K GaraMary R ZhangStephanie ShiffkaRazi RaziuddinLeonard M NeckersW Marston LinehanHaobin ChenGordon L HagerDavid S Schrump

Published in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2024)

NFIC is a key TF and possible mediator of transcriptional regulation by BET family proteins in SCLC. Our findings highlight the potential of genome-wide chromatin accessibility analysis for elucidating mechanisms of pulmonary carcinogenesis and identifying novel targets for lung cancer therapy.

Keyphrases

genome wide
nuclear factor
transcription factor

cancer therapy
genome wide analysis
dna methylation

toll like receptor
pulmonary hypertension
gene expression

dna damage
drug delivery
dna binding