Genome-Wide Analysis Identifies Nuclear Factor 1C as a Novel Transcription Factor and Potential Therapeutic Target in SCLC.
Vivek ShuklaHaitao WangLyuba VarticovskiSongjoon BaekRuihong WangXinwei WuFrank EchtenkampFrank Villa-HernandezKatherine P ProthroSudheer K GaraMary R ZhangStephanie ShiffkaRazi RaziuddinLeonard M NeckersW Marston LinehanHaobin ChenGordon L HagerDavid S SchrumpPublished in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2024)
NFIC is a key TF and possible mediator of transcriptional regulation by BET family proteins in SCLC. Our findings highlight the potential of genome-wide chromatin accessibility analysis for elucidating mechanisms of pulmonary carcinogenesis and identifying novel targets for lung cancer therapy.