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Genome-Wide Analysis Identifies Nuclear Factor 1C as a Novel Transcription Factor and Potential Therapeutic Target in SCLC.

Vivek ShuklaHaitao WangLyuba VarticovskiSongjoon BaekRuihong WangXinwei WuFrank EchtenkampFrank Villa-HernandezKatherine P ProthroSudheer K GaraMary R ZhangStephanie ShiffkaRazi RaziuddinLeonard M NeckersW Marston LinehanHaobin ChenGordon L HagerDavid S Schrump
Published in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2024)
NFIC is a key TF and possible mediator of transcriptional regulation by BET family proteins in SCLC. Our findings highlight the potential of genome-wide chromatin accessibility analysis for elucidating mechanisms of pulmonary carcinogenesis and identifying novel targets for lung cancer therapy.
Keyphrases
  • genome wide
  • nuclear factor
  • transcription factor
  • cancer therapy
  • genome wide analysis
  • dna methylation
  • toll like receptor
  • pulmonary hypertension
  • gene expression
  • dna damage
  • drug delivery
  • dna binding