Absolute quantitation of acetaminophen-modified human serum albumin in acute liver failure patients by liquid chromatography/tandem mass spectrometry.
Timon GeibAndré LeBlancTze Chieh ShiaoRené RoyElaine M LeslieConstantine J KarvellasLekha SlenoPublished in: Rapid communications in mass spectrometry : RCM (2019)
A fast and sensitive assay was developed to accurately quantify NAPQI-HSA as a biomarker for APAP-related covalent binding in human serum.
Keyphrases
- liver failure
- liquid chromatography tandem mass spectrometry
- hepatitis b virus
- human serum albumin
- ms ms
- simultaneous determination
- end stage renal disease
- newly diagnosed
- solid phase extraction
- ejection fraction
- mass spectrometry
- drug induced
- liver injury
- high throughput
- patient reported outcomes
- intensive care unit
- aortic dissection
- transcription factor
- single cell