Associations of combined polygenic risk score and glycemic status with atrial fibrillation, coronary artery disease and ischemic stroke.
Juntae KimDongmin KimHan-Joon BaeByoung-Eun ParkTae Soo KangSeong-Hoon LimSu Yeon LeeYoung Hak ChungJi Wung RyuMyung-Yong LeePil-Sung YangBoyoung JoungPublished in: Cardiovascular diabetology (2024)
Our results suggest that the nature of the dose-dependent relationship between HbA1c levels and cardiovascular disease in individuals with different PRS is outcome-specific. This adds to the evidence that PRS may play a role together with glycemic status in the development of cardiovascular disease.
Keyphrases
- cardiovascular disease
- type diabetes
- atrial fibrillation
- coronary artery disease
- cardiovascular events
- percutaneous coronary intervention
- glycemic control
- oral anticoagulants
- left atrial
- cardiovascular risk factors
- catheter ablation
- heart failure
- direct oral anticoagulants
- coronary artery bypass grafting
- left atrial appendage
- acute coronary syndrome
- aortic valve
- mitral valve
- transcatheter aortic valve replacement