Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism.
Stephen P SchauerChang Hoon ChoGloriia NovikovaGillie A RothJulie LeeAnup D SharmaAlejandro R FoleyCarl NgPhilip ShenMeena ChoiTaylur P MaLilian PhuHanna G BudayevaTommy K CheungGuita LalehzadehJose ImperioHai NguAinhoa EtxeberriaYuxin LiangMitchell G RezzonicoMichelle DouradoKevin HuangZijuan LaiMartha HokomNikhil J PandyaDwight NewtonAlyaa M Abdel-HaleemPamela ChanDonna LeeNardos G TassewDewakar SangarajuDeborah O'ConnorIsidro HötzelKimberly L StarkCarolina ChouOded ForemanAmy EastonKristin R WildsmithGizette SperindeChristopher M RoseBrad A FriedmanReina N FujiRobby M WeimerWilliam J MeilandtShraddha SadekarAlicia A NugentAnne BieverPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
CSF soluble triggering receptor expressed on myeloid cells 2 (sTREM2) reflects brain target engagement for a novel TREM2 agonist, hPara.09. CSF chitinase-3-like protein 1 reflects microglial TREM2 agonism. Both can be used as clinical fluid biomarkers to monitor TREM2 activity in brain.
Keyphrases
- cerebrospinal fluid
- resting state
- white matter
- functional connectivity
- induced apoptosis
- bone marrow
- social media
- acute myeloid leukemia
- dendritic cells
- cell cycle arrest
- multiple sclerosis
- immune response
- cell proliferation
- oxidative stress
- endoplasmic reticulum stress
- spinal cord injury
- brain injury
- binding protein
- lps induced
- pi k akt